Can Changing When And What We Eat Help Outwit Disease?

Eating. It’s what I was born to do, apparently. And now there’s this: #intermittentfasting update soon!

A photo posted by brandie jefferson (@missaligned) on Jan 30, 2017 at 8:04am PST

I was worried that I might not be able to stick to an intermittent fasting schedule during my vacation in Mexico. It turns out, it was a breeze.

Because I was sick.

It started on the plane ride to Cozumel, a tingle in my throat and then the telltale sign that illness was imminent: three sneezes in a row. A clogged nose, a slight fever and a general feeling of malaise came over me after my third dive into the electric blue waters of the Caribbean.

I’m participating in a preliminary study at Johns Hopkins Medicine on the effects of intermittent fasting on the microbiome and inflammation in people with multiple sclerosis. For the six-month study, I’m restricted to eating during an eight-hour period, usually from noon until 8 p.m. That meant that the first day of vacation, my first meal was pretzels on a plane, my second was ceviche and nachos in the late afternoon.

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It wasn’t a great combination, but I had a feeling that as my nose continued to clog, I wouldn’t be able to taste much, so I went for variety. As the week went on, I tried not to let my inability to taste hamper the experience, but it was hard. Tacos tasted like rubber, plantains like Elmer’s glue. And though I squealed in delight when I saw a churros cart, the deep-fried, buttery, cinnamon-sugary treats tasted more like cardboard covered in sawdust.

My vacation was headed toward gastronomic disaster, but at least the study data would not be compromised.

At the end of the six months, researchers will be looking at the state of my microbiome, via a stool sample, to determine how it may have changed. Or to be precise, my microbiota, according to Jorge Cervantes, an assistant professor of microbiology at the Texas Tech University Health Sciences Center, El Paso who has studied the microbiome in relation to several diseases, including MS. I called him to get up to speed on my microbiota.

“The microbiota is all the microorganisms living in a specific niche,” he says. That niche being my gut. “We talk about bacteria, mainly, but there are also viruses and fungi.”

The microbiome is the whole ecosystem — the bacteria, viruses, fungi, as well as the environmental conditions they inhabit.

Our resident bacteria serve us in three basic ways, says Cervantes, who is not involved in the study I’m doing. They occupy space and help restrict the overgrowth of bad bacteria. And they can help our metabolism by facilitating the breakdown of certain molecules.

Gut bacteria are of special interest to people with autoimmune diseases, including multiple sclerosis, irritable bowel syndrome and Crohn’s disease, because they help in the training and development of our immune systems.

That’s so that your immune system can sample a molecule and and tell, “‘Oh this is bacteria,’ or ‘Oh, this is a virus.’ ” Cervantes explains. If the molecule might cause harm, an immune response is triggered.

Once an immune cell locates a potentially harmful molecule — say, from the bacteria Streptococcus, or whatever I caught on the plane to Mexico — it sends out a call to other immune cells so they can help control the invasion, Cervantes says. That process creates inflammation, which can involve pain, stinging, swelling or a host of other unpleasant symptoms that ordinarily mean your body is fighting the good fight to help you heal.

“Sometimes,” Cervantes said, “the immune cells get confused.” And here’s where our microbes can affect autoimmune diseases such as MS, in which the body’s immune system fires up at the wrong times: bacteria can be the trigger for this confusion. An immune cell can mistake good bacteria for bad bacteria, and that confusion can lead to an immune response when there’s no real threat to a person’s health.

Scientists are not only studying microbiota and their relationship to autoimmune diseases, they’re studying their roles in hypertension, cancer, even mental health disorders.

Research in many of these areas is new and exciting and full of potential — and faces challenges, one being the difficulty of teasing out cause and effect. Does a change in the volume and/or variety of a microbiota lead to disease? Does the disease change the microbiota, leading to other health changes?

“The thing is, no one knows what is first, the egg or the chicken,” Cervantes says.

To answer that question, scientists have been turning to mice. Not just any mice, these rodents are squeaky-clean, entirely germ-free. According to a review published in 2015 in Microbial Ecology in Health and Disease, germ-free mice are less likely to have inflammatory bowel disease, autoimmune arthritis, Type 1 diabetes and other autoimmune diseases. And when they do have them, the symptoms are less severe.

This, the authors say, is consistent with the idea that the microbiota could be a trigger for these diseases. Good news, right? But they go on to say that attempts to identify exactly which organisms could be causing these diseases have failed.

And even if we can agree that we want a “healthy” gut microbiome, what does that mean? “There is no ideal,” Cervantes says. “The point is that the microbiome is not a fixed entity.” It changes over time and is different from person to person.

And so it seems we’ve added a third variable to the already complex interplay of genetics and the environment when considering health and disease.

I’m pleased to report that my immune system, while it may be overactive, also does its job once in a while, fighting back the infection as I hunkered down in my hotel room in Mexico.

While I recuperated, I read through comments on the first article I wrote about my experiences with this study. People shared their own attempts to tweak their diets as means to ease suffering from a host of diseases. I also read a lot of criticism about my diet:

However, what she is eating are not anti-inflammatory foods at all! Why not start there and give the body more of a fighting chance than to eat the SAD (standard American diet)

less ice cream & tacos, more #fruit, #veg, #wholegrains, #beans etc & this could be a real winner for #multiplesclerosis

Darlin try cannabis its amazing for MS

“Who do these people think they are?” I thought. I mean, ramen is delicious, tacos are a mainstay of my diet, and ice cream is pretty much perfect.

Many people with MS do have foods that they know don’t sit well with them; for me, one is pizza. Delicious pizza. After a few slices my hands and feet burn and I typically fall asleep within the hour. To be honest, my body isn’t a fan of ice cream, either. And I can’t say I felt great after that ramen.

Halfway into the study, and I haven’t felt much better overall. The first thing I do when I get home from work every day is still nap. I still grab my trusty ice pack from the freezer about once a week and clutch it for the soothing effect it has on my hands, and occasionally my feet. Don’t worry; I wash it!

So OK, maybe the commenters are on to something. It stands to reason that if when you eat can have a drastic impact on the microorganisms in your gut, then certainly what you eat must be important, too, right?

“By all means,” Cervantes said.

My study isn’t looking at the effect of particular foods on MS symptoms. But I must admit I’ve been eating much worse since the study began. Come noon, I am so focused on food that I inhale everything in sight, then forage for more.

One co-worker frequently reminds us via email that he has Hershey’s Kisses in his office. Another introduced me to Peanut Chews — she kindly always has a pack waiting for me in her desk drawer. The convenience store downstairs has granola bars for 75 cents! (And french fries for $1.50.)

Most days I eat my typically healthy lunch (some haphazard mix of vegetables topped with last night’s dinner protein) and before I’ve finished chewing the last bite, before I can rationally asses the state of my hunger, I’m out of my office looking for another food fix.

There’s another reason I’ve continued to eat like a madwoman during these past three months. Over the past year, I’ve deliberately lost a good amount of weight. Let’s call it 35 pounds. Despite my unhealthy recent eating habits, believe it or not, I did it through an overhaul in my diet, cutting out most simple carbs and eating more vegetables and trading fat for muscle mass.

And like so many women, I do still reflexively judge how healthy I am in part by how much I weigh. I lost a few pounds when I began the study, and no matter how much ice cream I shovel into my face, I haven’t gained any of it back.

I’m no doctor, but I’m fairly certain that just because my weight is stable, that doesn’t mean I’m on a path to perfect health or a flourishing microbiome.

And so for the second half of the study, I have resigned myself to a crazy idea, getting back to eating like a responsible human being. A person who cares about the well-being of the ecosystem I’m hosting: the bacteria, viruses and other little guys who call my gut home.

Farewell, Peanut Chews. 🙂

Brandie Michelle Jefferson is a communications manager and freelance reporter who loves a good science story. She’s on Twitter, too: @b_m_jefferson.

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After Turbulent Week, Trump Holds Campaign Rally

President Donald Trump pumps his fist to supporters at the conclusion of a campaign rally Saturday in Melbourne, Fla.

Chris O’Meara/AP

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A month into his term, President Donald Trump hit the trail Saturday for what a White House spokeswoman called a “campaign rally for America.” At Orlando Melbourne International Airport in Florida, Trump addressed a hangar packed with supporters in an event organized not by the White House but by Trump’s own campaign committee.

“I’m here because I want to be among my friends and among the people,” Trump told the enthusiastic crowd before running through a long list of campaign promises and what he said were his administration’s early accomplishments.

“Jobs are already starting to pour back in,” Trump told the cheering crowd. On Obamacare, he promised a plan to repeal and replace it in “a few weeks.” Of the U.S.’ participation in the controversial Trans-Pacific Partnership, he said, “just terminated.”

Talk of Air Force One cost-saving? Check. Reviving the Keystone pipeline? Check. Criticizing violence in America’s inner cities? Check. Singling out Chicago for its rising murder rate, Trump declared that “safety is a civil right, and we will fight to make America totally safe again.”

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On his executive order temporarily banning travel from seven majority-Muslim countries that was put on hold by the Ninth Circuit Court of Appeals, Trump promised “we never give up” and that “we will do something next week. I think you’ll be impressed.” In one of his biggest applause lines, the president talked of doing what it takes “to keep radical Islamic terrorists the hell out of our country.”

The Florida rally stood in stark contrast to the difficult week Trump had in Washington. On Monday, he fired his national security advisor, Michael Flynn, after reports that Flynn had discussed sanctions with Russia’s ambassador before Trump’s inauguration. On Wednesday, Trump’s choice to lead the Department of Labor, fast food executive Andrew Puzder, withdrew his name from consideration after it became clear he lacked the support to survive a Senate confirmation vote.

While the rally may have seemed like an attempt at a fresh start, “I wouldn’t call it a reset,” White House Chief of Staff Reince Priebus told The Washington Post on Saturday, “because we’re quite proud of a lot of the achievements over the past four weeks.”

So, not a reset — but a rousing stump speech meant to take his message directly to the people. Supporter James Evert, who turned out for the rally, also saw it as a chance for Trump’s supporters to give the President a boost.

“Living in Washington and dealing with all the bureaucracy and all the media and a lot of the bias,” Evert told NPR, “you know you probably get berated by all the negativity. And then you come to one of these things, and it’s probably a refreshing moment [for Trump]. He says, ‘Okay, these are the grassroots people. These are hardworking Americans, and they’re here to see me and root me on and encourage me and kind of revive my momentum.’ “

A smaller group protesting Trump gathered across the road from the hangar, waving signs and chanting.

Trump began the rally by continuing his attacks on the media, telling the crowd he wanted to speak “without the filter of the fake news. The dishonest media which has published one false story after another, with no sources — even though they pretend they have them — they make them up in many cases. They just don’t want to report the truth.”

Trump has stepped up his criticism of the media in the past week. On Thursday, he repeatedly berated reporters and decried their coverage as “fake news” in a contentious, 77-minute news conference. He then tweeted Friday that “The FAKE NEWS media (failing @nytimes, @NBCNews, @ABC, @CBS, @CNN) is not my enemy, it is the enemy of the American People!”

Trump’s suspicion of and animosity toward the press clearly resonated with many in the crowd, including Jim Sava.

“The news media has this concept that they can take Donald Trump down,” Sava said. “There’s nothing they can do to take him down. There’s nothing. The only person that could take Donald Trump down is Donald Trump. If he does not do what he said he was gonna do, that would be what has to happen to lose support from the people. The people are fed up and we just want America to be great again.”

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